Sistema Digestório: Integração Básico-Clínica

Fármacos para o Controle da Acidez Gástrica e Protetores da Mucosa

Santos, Flávia Almeida; Rao, Vietla Satyanarayana;

Resumo:

A secreção ácida gástrica pelas células parietais do estômago é um processo dinâmico regulado por vias neurais, hormonais e parácrinas, a nível central e periférico, assim como por estímulos mecânicos e químicos. Os principais estimulantes da produção ácida pelas células parietais são a histamina, a acetilcolina e a gastrina.A secreção ácida estomacal facilita a digestão de proteínas, a absorção de ferro, cálcio e vitamina B12, e reduz o risco de infecções gastrintestinais (Helicobacter pylori, Vibrio cholera, Salmonella sp., dentre outros). Uma secreção ácida insuficiente pode resultar em má absorção e aumento na susceptibilidade a infecções gastrintestinais, enquanto excesso de secreção ácida pode causar desde a doença do refluxo gastroesofágico e úlcera péptica até danos mais severos à mucosa como podem ser vistos na síndrome de Zollinger–Ellison.

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DOI: 10.5151/9788580391893-23

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Como citar:

SANTOS, Flávia Almeida; RAO, Vietla Satyanarayana; "Fármacos para o Controle da Acidez Gástrica e Protetores da Mucosa", p. 645 -670. In: Sistema Digestório: Integração Básico-Clínica. São Paulo: Blucher, 2016.
ISBN: 9788580391893, DOI 10.5151/9788580391893-23