Embriologia do Pâncreas e Sistema Hepatobiliar

Ogias, Daniela ; Oriá, Reinaldo B. ; Bevilacqua, Estela

Resumo:

O pâncreas embrionário é constituído de evaginações do endoderma ventral e dorsal do intestino anterior primitivo próximo à junção com o intestino médio. Estes brotos endodérmicos crescem e se fusionam durante o desenvolvimento, para formar o pâncreas. As células progenitoras endodérmicas destas regiões darão origem às linhagens de células dutais, acinares e endócrinas.

Download (PDF)

126 downloads

Sistema, digestório

DOI: 10.5151/9788580391893-07

Referências bibliográficas
  • BOGUE, C. W.; GANEA, G. R.; STURM, E.; IANUCCI, R.; JACOBS, H. C. Hex Expression Suggests a Role in the Development and Function of Organs Derived From Foregut Endoderm. Dev. Dyn. 219: 84-9, 2000.
  • BORT, R.; SIGNORE, M.; TREMBLAY, K.; MARTINEZ-BARBERA, J. P.; ZARET, K. S. Hex homeobox gene controls the transition of the endoderm to a pseudostratifi ed, cell emergent epithelium for liver bud development. Dev. Biol. 290(1): 44-5, 2006.
  • CALMONT, A.; WANDZIOCH, E.; TREMBLAY, K. D.; MINOWADA, G.; KAESTNER, K. H. ET AL. An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. Dev. Cell. 11: 339–48, 2006. DOI: 10.1016/j.devcel.2006.06.015
  • CARDINALE, V.; WANG, Y.; CARPINO, G.; MENDEL, G.; ALPINI, G. ET AL. The biliary tree—a reservoir of multipotent stem cells. Nat. Rev. Gastroenterol Hepatol. 9: 231-40, 2012. DOI:10.1038/nrgastro.2012.23
  • FRANTZ, E. D.; PEIXOTO-SILVA, N.; PINHEIRO-MULDER, A. Endocrine pancreas development: effects of metabolic and intergenerational programming caused by a protein-restricted diet. Pancreas. 41(1): 1-9, 2012. DOI: 10.1097/MPA.0b013e3182236320.
  • GANNON, M.; GAMER, L. W.; WRIGHT, C. V. Regulatory regions driving developmental and tissue-specifi c expression of the essential pancreatic gene Pdx1. Dev. Biol. 238(1): 185–201, 2001.
  • GAO, N.; LELAY, J.; VATAMANIUK, M. Z.; RIECK, S.; FRIEDMAN, J. R.; KAESTNER, K. H. Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev. 22(24): 3435–48, 2008.
  • GITTES, G. K. Developmental biology of the pancreas: a comprehensive review. Dev. Biol. 326(1): 4-35, 2009. DOI: 10.1016/j.ydbio.2008. 10.024.
  • GROTH, C.; FORTINI, M. E. Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Semin. Cell Dev. Biol. 23(4): 465-72, 2012.
  • HEBROK, M.; KIM, S. K.; MELTON, D. A. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 12(11): 1705-13, 1998.
  • HEINIS, M.; SIMON, M. T.; DUVILLIE, B. New insights into endocrine pancreatic development The role of environmental factors. Horm. Res. Paediatr. 74(2): 77-82, 2010. DOI: 10.1159/000314894
  • HUNTER, M. P.; WILSON, C. M.; JIANG, X.; CONG, R.; VASAVADA, H. ET AL. The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Dev. Biol. 308(2): 355-67, 2007.
  • JORGENSEN, M. C.; AHNFELT-RONNE, J.; HALD, J.; MADSEN, O. D.; SERUP, P.; HECKSHER-SORENSEN, J. An illustrated review of early pancreas development in the mouse. Endocr. Rev. 28(6): 685-705, 2007.
  • JUNG, J.; ZHENG, M.; GOLDFARB, M.; ZARET, K. S. Initiation of mammalian liver development from endoderm by fi broblasts growth factors. Science. 284:1998-2003, 2003.
  • REICHERT, M.; RUSTGI, A. K. Pancreatic ductal cells in development, regeneration, and neoplasia. J. Clin. Invest. 121(12): 4572-8, 2011.
  • ROJAS, A.; KHOO, A.; TEJEDO, J. R.; BEDOYA, F. J.; SORIA, B.; MARTÍN, F. Islet cell development. Adv. Exp. Med. Biol. 654: 59-75, 2010. DOI: 10.1007/978-90-481-3271-3_4.
  • ROSKAMS, W.; DESMET, V. Embryology of extra- and intrahepatic bile ducts, the ductal plate. Anat. Rec. 291: 628–35, 2008.
  • ROSSI, J. M.; DUNN, N. R.; HOGAN, B. L.; ZARET, K. S. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination forhepatogenesis from the endoderm. Genes Dev. 15(15): 1998-2009, 2001.
  • SEYMOUR, P. A.; SANDER, M. Historical Perspective: beginnings of the b-Cell. Current perspectives in β-cell development. Diabetes. 60: 364-76, 2011.
  • SPAGNOLI, F. M.; BRIVANLOU, A. H. The Gata5 target, TGIF2, defi nes the pancreatic region by modulating BMP signals within the endoderm. Development. 135: 451-61, 2008. DOI:10.1242/dev.008458
  • SUGIYAMA, Y.; TAKABE, Y.; NAKAKURA, T.; TANAKA, S.; KOIKE, T.; SHIOJIRI, N. Sinusoid development and morphogenesis may be stimulated by VEGF-Flk-1 signaling during fetal mouse liver development. Dev. Dyn. 239(2): 386-97, 2010.
  • SUGIYAMA, Y.; TAKABE, Y.; YAGI, S.; KOIKE, T.; SHIOJIRI, N. Immunomagnetic exclusion ofPECAM-1-positive endothelial cells in fetal mouse liver cell cultures causes impaired growth and gene expression of hepatoblasts and stellate cells. Biomed. Res. 35(4): 271-83, 2014.
  • UEMURA, M.; IGARASHI, H.; OZAWA, A.; TSUNEKAWA, N.; KUROHMARU, M. ET AL. Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of mouse early somite-stage embryos. J. Vet. Med. Sci. 77(5): 587-91, 2015. DOI: 10.1292/jvms.14-0635
  • VAKILI, K.; POMFRET, E. A. Biliary Anatomy and Embryology. Surg. Clin. N. Am. 88: 1159-74, 2008.
  • WANG, J.; RHEE, S.; PALARIA, A.; TREMBLAY, K. D. FGF signaling is required for anterior but not posterior specifi cation of the murine liver bud. Dev. Dyn. 244(3): 431-43, 2015. DOI: 10.1002/dvdy.24215.
  • WELLS, J. M.; MELTON, D. A. Vertebrate endoderm development. Annu. Rev. Cell Dev. Biol. 15: 393-410, 1999.
  • YOSHIDA, M.; NISHIKAWA, Y.; OMORI, Y.; YOSHIOKA, T.; TOKAIRIN, T. ET AL. Involvement of signaling of VEGF and TGF-beta in differentiation of sinusoidal endothelial cells during culture of fetal rat liver cells. Cell Tissue Res. 329(2): 273-82, 2007.
  • ZHANG, W.; YATSKIEVYCH, T. A.; CAO, X.; ANTIN, P. B. Regulation of Hex gene expression by a Smads-dependent signaling pathway. J. Biol. Chem. 277(47): 45435-41, 2002.
Como citar:

OGIAS, Daniela; ORIÁ, Reinaldo B.; BEVILACQUA, Estela; "Embriologia do Pâncreas e Sistema Hepatobiliar", p. 179-196. Sistema digestório: integração básico-clínica. São Paulo: Blucher, 2016.
ISBN: 9788580391893, DOI 10.5151/9788580391893-07